LPS increased the oxidative stress andĭecreased the anti-oxidant glutathione in the tissue of the LPS-treated mothers and pups. (LPS) at a single dose of 2.5 mg/kg of body weight at the 7th day of gestation. Pregnant Swiss female mice were intraperitonealy injected with the acute bacterial lipopolysaccharides This study aimed to investigate septic complications resulted in behavioral changes in mice Our work demonstrates that NA, VB2, and VC cross-talk with each other that act as a more potent biochemical chain of antioxidant defense against TAA-induced toxicities in vivo. However, the combination of the three vitamins was found more effective as compared to each of the vitamins. Rats administered with NA, VB2, and VC as individually or in combination ameliorated the deleterious effects of TAA that was confirmed by histopathology.

Moreover, malondialdehyde (MDA), hydroxyproline and nitic oxide (NO) were also significantly increased in the TAA-treated rats, while reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were significantly compromised in the hepatic samples. Treatment of rats with TAA led to a significant elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total bilirubin, cholesterol, triglycerides, low-density lipoprotein (LDL) and tumor necrosis factor-alpha (TNF-α) in the serum samples. TAA + NA + VB + VC group (rats administered the with the three vitamins daily in TAA pre-injected at the respective doses described above). Thirty-six albino rats were divided into six groups: Control group TAA group (IP injection with TAA at a dosage of 200 mg/Kg three times a week for two months) TAA + NA group (rats administered with NA at a dosage of 200 mg/kg daily besides TAA as in the control) TAA + VB2 group (rats administered with vitamin B2 at a dosage of 30 mg/kg daily besides injection with TAA) TAA + VC group (rats administered with vitamin C at a dosage of 200 mg/kg daily along with injection of TAA). In the present study, we have investigated if the strong antioxidant power of Nicotinamide (NA), Vitamin B2 (VB2), and Vitamin C (VC) can ameliorate TAA-induced oxidative stress-mediated liver injury in the rats. Oxidative stress is attributed to such pathological condition that further contributes to the initiation and progression of liver injury. The liver disease is one of the most important traditional public health problems in Egypt. Since it belongs to nutrients that are essential for. The number of the intertrial crossings between the two compartments, the number of stimulating crossings and the number of the reinforced crossing between the two compartments ( Figure 5) were significantly decreased. They showed a dose-dependent significant increase of the latency to avoid the shock. The pups born to selenite-treated mothers did not learn to avoid the unconditioned stimulus and the number of crossings during the conditioned stimulus decreased over time during the experiment. It was observed that the control groups learned to avoid the unconditioned stimulus by running into the other compartment during the unconditioned stimulus on almost all days of the experiment and recorded high success rates of avoidance response ( Figure 4).

Impairment of active avoidance learning in all tested groups was clearly observed. of learning showed that high concentration of selenite has impaired the avoidance conditioning in the shuttle box.

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